Circulation on the Run

This week, join author Vivek Reddy and Senior Associate Editor Sana Al-Khatib as they discuss the article "High-Voltage Focal Pulsed Field Ablation to Treat Scar-Related Ventricular Tachycardia: The First-in-Human VCAS Trial."

For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20251215.75602

This week, join author Sara Moura-Ferreira and Associate Editor Ntobeko Ntusi as they discuss the article "Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20251208.238882

This week, join author Hans-Josef Feistritzer and Associate Editor Stefan James as they discuss the article "Peri-Interventional Anesthesia Strategies for Transcatheter Aortic Valve Implantation: A Multicenter, Randomized, Controlled, Noninferiority Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251201.586148

This week, join author Jonas Oldgren and Associate Editor Torbjørn Omland as they discuss the article "Biomarker-Based ABC-AF Risk Scores for Personalized Treatment to Reduce Stroke or Death in Atrial Fibrillation: A Registry-Based Multicenter, Randomized, Controlled Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251124.61165

This week, join Associate Editor and Editorialist Graeme Hankey as he discusses the article "Bailout Intracranial Angioplasty or Stenting After Thrombectomy for Acute Large Vessel Occlusion: 1-Year Outcomes of ANGEL-REBOOT and the editorial "Unsuccessful Thrombectomy During Acute Ischemic Stroke: Can It Be Rescued by Angioplasty and/or Stenting?"

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251117.229007

This week, please join authors Shingo Fukuma and Yuichiro Mori as well as Associate Editor Shinya Goto as they discuss the article "Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251110.703752

This week, join author Rohan Khera and Associate Editor Nicholas Mills as they discuss the article "Phenotypic Selectivity of Artificial Intelligence-enhanced Electrocardiography in Cardiovascular Diagnosis and Risk Prediction."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20251103.917420

This week, Marc Ruel guest-hosts in this episode of Circulation on the Run as it features the annual Surgery Issue for Circulation. First, Marc is joined by author Duk-Hyun Kang as they discuss his article "Comparison of Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis." Then Marc is joined by authors Enoch Akowuah and Janelle Wagnild as they discuss their article "Accelerometer-Measured Physical Activity After Mitral Valve Surgery: An Analysis of the UK Mini Mitral Randomized Controlled Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251027.193601<...

This week, please join author Torbjørn Omland, as he discusses the article "Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251020.442597

This week, please join author Emily Lau, editorialist Sadiya Khan, and Associate Editor Kelly Chin as they discuss the article "Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort" and the editorial "Bending the Curve in Maternal Mortality: Pregnancy as a Moment for Cardiovascular Disease Prevention."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251013.381115

This week, please join author Emily Lau, editorialist Sadiya Khan, and Associate Editor Kelly Chin as they discuss the article "Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort" and the editorial "Bending the Curve in Maternal Mortality: Pregnancy as a Moment for Cardiovascular Disease Prevention."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20251013.381115

This week, please join authors Joseph Campain and Gregory Lewis, as well as Section Editor Satyam "Tom" Sarma as they discuss the article "Characterization and Application of Novel Exercise Recovery Patterns That Reflect Cardiac Performance: A Substudy of the SEQUOIA-HCM Randomized Trial."

For the episode transcript, visit: https://staging.www.ahajournals.org/do/10.1161/podcast.20251006.208532

This week please join author Gregory Hundemer, Editorialist Wanpen Vonpatanasin, and Associate Editor Torbjørn Omland as they discuss the article "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study" and the editorial "Subclinical Primary Aldosteronism: A Potential New Target in Cardiovascular Prevention?"

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20250929.481570

This week please join author Chetan Huded as he discusses the article "Health Status Outcomes with Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA."

For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20250922.194514

This week, please join Daniel W. Jones as he discusses updates found in the 2025 AHA/ACC High Blood Pressure Guideline. This is an important episode to learn of the changes in guidelines and recommended practices in treating high blood pressure.

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250912.590432

This week please join author Daniele Giacoppo as he discusses the article "Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250908.794818

This week please join author Rebecca Lawn and Associate Editor Mercedes Carnethon as they discuss the article "Experiences of Stalking and Obtaining a Restraining Order Are Associated With Onset of Cardiovascular Events in Women: A Prospective Analysis in the Nurses' Health Study II."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250902.860161

This week please join author Sheri Hartman and Associate Editor Jarett Berry as they discuss the article "Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250825.890592

This week please join authors Eric Olson and Qianqian Ding, and Senior Guest Editor Gianluigi Condorelli as they discuss the article "Genomic Editing of a Pathogenic Sequence Variant in ACTA2 Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250818.61174

This week please join author Joachim Skovbo and Associate Editor Brendan Everett as they discuss the article "Association of Statin Treatment and Dose With the Clinical Course of Small Abdominal Aortic Aneurysms in Men: A 5-Year Prospective Cohort Study From 2 Population-Based Screening Trials."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250812.716960

This week please join author Christian Ruff and Associate Editor Andrea Russo as they discuss the article "Abelacimab Versus Rivaroxaban in Patients With Atrial Fibrillation on Antiplatelet Therapy: A Prespecified Analysis of the AZALEA-TIMI 71 Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20250804.510827

This week please join author Boyoung Joung and Associate Editor Svati Shah as they discuss the article "Proteomic Signatures for Risk Prediction of Atrial Fibrillation."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250728.351486

This week please join author Marek Hozman and Associate Editor Andrea Russo as they discuss the Original Research Article "COOPERATIVE-PFA: A Three-Arm Randomized Controlled Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250721.6011

This week's podcast is dedicated to Circulation's fifth annual Disparities issue. First, please join Associate Editor Karol Watson and Guest Editor Nilay Shah as they discuss the article "Centering Diné (Navajo) Voices: Barriers, Facilitators, and Perceptions of Cardiac Care Among Patients With Heart Failure in Rural Navajo Nation" with corresponding author Lauren Eberly. Then, Associate Editor Mercedes Carnethon and Guest Editor Nilay Shah discuss the Frame of Reference article "Health Equity: Are We There Yet?" with author Clyde Yancy. Don't miss this important episode!

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250710.251438

This week please join guest author Adam Griesemer and Associate Editor and Digital Strategies Editor Maryjane Farr as they discuss the Review Article "Cardiac Xenotransplantation: Current State and Future Directions."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250707.102697

This week please join guest host Susmita Sahoo and author Huize Pan as they discuss the article "Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease." Dr Pan and his coauthors are the recipients of the 2025 Joseph Loscalzo Award. This award recognizes the best basic/translational article published in Circulation in the preceding 12 months.

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250629.645452

This week please join author Yuxiang Dai and Associate Editor Esther Lutgens as they discuss the article "Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2–Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250623.661904

This week please join author Robert Clarke and Associate Editor Wendy Post as they discuss the article "Causal Relevance of Lp(a) for Coronary Heart Disease and Stroke Types in East Asian and European Ancestry Populations: A Mendelian Randomization Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250617.454324

This week please join author Nikolaus Marx as he discusses the article "Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250609.351110

This week please join author Brian Lindman and Executive Editor and Editorialist James de Lemos as they discuss the article "Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial" and the accompanying editorial "Biomarkers to Guide the Timing of Aortic Valve Replacement in Asymptomatic Aortic Stenosis: Where Do We Stand After Early TAVR?"

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250529.497472

This week please join author Varsha Tanguturi and Associate Editor Dharam Kumbhani as they discuss the article "Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: A Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250528.505920

This week please join author André Zimerman and Associate Editor Amit Khera as they discuss the article "Intensive Lowering of LDL Cholesterol Levels With Evolocumab in Autoimmune or Inflammatory Diseases: An Analysis of the FOURIER Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250519.268826

This week please join author Milind Desai and Associate Editor Mark Link as they discuss the article "Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results From VALOR-HCM."

 For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250512.476310

This week please join author Jarett Berry as well as Guest Editor and Editorialist Paul Thompson as they discuss the article "High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250505.656863

This week please join author Bin Zhou and Associate Editor Zhao Wang as they discuss the article "Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250428.805646

This week please join author Signe Glargaard and Associate Editor Justin Ezekowitz as they discuss the article "A Randomized Controlled Trial of Thoracentesis in Acute Heart Failure."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250421.239148

This week please join author Emmanuel Stamatakis and Associate Editor Jarett Berry as they discuss the article "Dose Response of Incidental Physical Activity Against Cardiovascular Events and Mortality."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250414.213483

This week please join author Barry Borlaug and Associate Editor Torbjørn Omland as they discuss the article "Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250407.806254

This week please join author Josef Stehlik as he discusses the article "Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250331.87307

This week please join author Josefine Windfeld-Mathiasen and Associate Editor Ntobeko Ntusi as they discuss the article "Cardiovascular Disease in Anabolic Androgenic Steroid Users."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250324.957173

This week please join author Eric Rosenthal and Associate Editor Gerald Greil as they discuss the article "Covered Stent Correction for Sinus Venosus Atrial Septal Defects, an Emerging Alternative to Surgical Repair: Results of an International Registry."

For the episode transcript, visit:  https://www.ahajournals.org/do/10.1161/podcast.20250317.309077

This week please join author Michael Zile and Associate Editor Justin Ezekowitz as they discuss the article "Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250307.892170

This week please join author Yugo Yamashita and Associate Editor Joshua Beckman as they discuss the article "Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial)."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250303.648421

This week please join author Carl Johann Hansen and Associate Editor Mark Link as they discuss the article "Declining Trend of Sudden Cardiac Death in Younger Individuals: A 20-Year Nationwide Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250224.873552

This week, Circulation celebrates Go Red for Women with its 9th annual special issue. Guest hosts Sana Al-Khatib and Mercedes Carnethon welcome authors Upasana (Paz) Tayal as well as Thais Coutinho and coauthors. Circulation on the Run also welcomes the American Heart Association's President Keith Churchwell.

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250217.870159

This week please join author Michael Zhang and Guest Editor Paul Gurbel as they discuss the article "Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS."

For the episode transcript, visit: https://www.ahajournals.org/do/110.1161/podcast.20250210.487047

This week please join author Paul Welsh and Guest Editor Manuel Mayr as they discuss the article "A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250203.163969

This week please join author Hayley Dillon and Editorialist Justin Canada as they discuss the article "Preventing Allogeneic Stem Cell Transplant−Related Cardiovascular Dysfunction: The ALLO-Active Trial" and the Editorial "Cardiorespiratory Fitness Assessment in Stem Cell Transplant Recipients: Getting to the Heart of the Problem."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250127.949759

This week please join author Olaf Bergmann as he discusses the article "A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20250121.427979

This week please join author Helga Gudmundsdottir and Editorialist James MacNamara as they discuss the article "Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial" and the accompanying Editorial "Cardiac Plasticity in Hypertrophic Cardiomyopathy: Exercise as Medicine?"

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250113.568188

This week please join author Kieran Docherty and Associate Editor Justin Ezekowitz as they discuss the article "Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20250106.356679

This New Year's week, please join Social Media Editor Pishoy Gouda as he interviews corresponding author Alexander Fanaroff to discuss the 2024 Willerson Award-winning article "Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20241227.771393

This week please join Circulation on the Run's newest host, Anezi Uzendu, author Boris Schmidt, and Associate Editor Andrea Russo as they discuss the article "Ablation Strategies for Repeat Procedures in Atrial Fibrillation Recurrences Despite Durable Pulmonary Vein Isolation: The Prospective Randomized ASTRO AF Multicenter Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20241216.546751

This week offers a double-feature of author interviews. First, please join author Gregg Stone as he discusses the article "Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial." Then, please join author Sung-Min Cho and our Circulation on the Run podcast host Greg Hundley as they discuss the article "Clinical Use of Bedside Portable Ultra-Low-Field Brain Magnetic Resonance Imaging in Patients on Extracorporeal Membrane Oxygenation: The Results From the Multicenter SAFE MRI ECMO Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241209.320025

This week, please join authors Amil Shah and our own Peder Myhre, as well as Guest Editor Allan Jaffe as they discuss the article "NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241202.603271

This week, please join author Robert Shaddy and Senior Associate Editor Victoria Delgado as they discuss the article "Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-blind Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20241125.19126

This week, please join author Gilles Montalescot, Editorialist John Carroll, and Associate Editor Dharam Kumbhani as they discuss the article "Flecainide to Prevent Atrial Arrhythmia after Patent Foramen Ovale Closure, the AFLOAT Study: A Randomized Clinical Trial" and the Editorial "Atrial Arrhythmias After PFO Device Closure: Common, Clinically Important, and Preventable?".

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241115.222442

This week, please join author Nigopan Gopalasingam, Editorialist B. Daan Westenbrink, and Associate Editor Justin Ezekowitz as they discuss the article "A Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction" and the editorial "Ketone Treatment in Heart Failure With Preserved Ejection Fraction: Recharging the Heart or Reducing Filling Pressures?".

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241111.585567

This week, please join author Kashish Goel and Associate Editor Dharam Kumbhani as they discuss the article "Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241104.791174

This week, please join authors Regina Royan and Tracy Madsen as well as Associate Editor Deborah Diercks as they discuss the article "Disparities in Emergency Medical Services Use, Prehospital Notification, and Symptom Onset to Arrival in Patients with Acute Stroke."

For the episode transcript, visit: https://www.ahajournals.org/do/110.1161/podcast.20241028.477927

This week, join Associate Editor Marc Ruel who briefly summarizes Circulation's annual Surgery Issue. Then he is joined by author André Lamy and they discuss the article "Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial." Then Marc is joined by author Niccolò Maurizi and they discuss the article "Long-Term Outcomes After Septal Reduction Therapies in Obstructive Hypertrophic Cardiomyopathy: Insights From the SHARE Registry."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20241018.445322

This week, please join authors Shaan Khurshid and Shinwan Kany as they discuss the article "Associations of 'Weekend Warrior' Physical Activity With Incident Disease and Cardiometabolic Health."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241003.112753

This week, please join author Luigi Di Biase as he discusses the article "Pulsed Field Ablation to Treat Paroxysmal Atrial Fibrillation: Safety and Effectiveness in the ADMIRE Pivotal Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241003.273130

This week, please join author Marcelo Di Carli and Associate Editor Vlad Zaha as they discuss the article "Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension."

This week, please join author Chen Chen and Associate Editor Sergio Lavandero as they discuss the article "LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240920.99651

This week, please join a panel session with authors Timothy Poterucha and David Ouyang, Editorialist Anna Sannino, and Senior Associate Editor Victoria Delgado as they discuss the Original Research Articles "Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR)" and "High-Throughput Deep Learning Detection of Mitral Regurgitation."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240916.127413

This week, please join author Bruce Wasserman and Associate Editor Mercedes Carnethon as they discuss the article "Intracranial Atherosclerotic Disease and Incident Dementia: the Atherosclerosis Risk in Communities Study (ARIC)."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240906.944975

This week, please join author Gregory Wyant and Associate Editor Gabriele Schiattarella as they discuss the article "Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240830.316198

This week, please join author Gary Owens and Associate Editor Iris Jaffe as they discuss the article "A Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240825.966308

This week, please join author Marius Hoeper and Associate Editor Kelly Chin as they discuss the article "Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized, Controlled Phase 3 Study."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240816.125469

This week, please join author Rachel Lampert as she discusses the article "Vigorous Exercise in Patients with the Congenital Long-QT Syndrome: Results of the Prospective, Observational, Multinational, LIVE-LQTS Study."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240809.114150

This week, please join author Hiroyuki Daida and Associate Editor Amit Khera as they discuss the article "A Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy−Statin and Eicosapentaenoic Acid (RESPECT-EPA)."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240804.906883

This week, please join author Rod Passman and Associate Editor Mark Link as they discuss the article "Association of Atrial Fibrillation Burden and Mortality Among Patients With Cardiac Implantable Electronic Devices."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240729.689092

This week, please join author John J.V. McMurray and Guest Editor Frank Ruschitzka as they discuss the article "Effect of Sacubitril/Valsartan on Cognitive Function in Patients With HFpEF: A Prespecified Analysis of PARAGON-HF."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240719.555489

This week, Circulation is proud to present the 4th annual Disparities issue. First, Guest Editor Latha Palaniappan leads the interview with author Jennifer Green as they discuss the article "Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial." Then, Disparities Editor Mercedes Carnethon talks with author Benjamin Zielonka about his article "Childhood Opportunity and Acute Interstage Outcomes: A National Pediatric Cardiology Quality Improvement Collaborative Analysis." Finally, Dr. Karol Watson leads the discussion with author Lisa Cooper regarding her article "Equitable Care for...

This week, please join first author Heerajnarain Bulluck as he discusses the article "Effect of Cangrelor on Infarct Size in ST-Segment−Elevation Myocardial Infarction Treated By Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (The PITRI Trial)."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240703.90241

This week, please join authors Reza Nezafat, Shiro Nakamori, and Amine Amyar as they discuss the article "Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240628.66549

This week, please join Social Media Editors Shirin Doroudgar and Susmita Sahoo as they speak with the 2024 Loscalzo Award recipient, Mark C. Blaser, regarding his article "Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis." The Loscalzo Award recognizes the best Basic/Translational article published in Circulation in the preceding 12 months.

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240621.715149

This week, please join author Laura Galian-Gay and Associate Editor Joshua Beckman as they discuss the article "Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240614.566029

This week, please join author David Kandzari and Associate Editor Wanpen Vongpatanasin as they discuss the article "Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240607.177703

This week, please join author Siddharth Patel and Guest Editor Ileana Piña as they discuss the article "Sodium-Glucose Cotransporter 2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240531.705195

This week, please join authors Jonathan Leor and Tal Caller, as well as Associate Editor Gabriele Schiattarella as they discuss the article "Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240524.921966

This week, please join author Adrian Hernandez as he discusses the article "Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240515.717282

This week, please join author Stephan Rosenkranz, Editorialist Lewis Rubin, and Associate Editor Kelly Chin as they discuss the article "Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era" and the Editorial "Is There a Role for Calcium Channel Blockers in the Contemporary Treatment Paradigm for Pulmonary Arterial Hypertension?"

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240510.641533

This week, please join author Kristoffer Berg-Hansen and Section Editor and Editorialist Stayam "Tom" Sarma as they discuss the article "Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240503.968091

This week, please join author Amy Lin and Statistical Editor Dan (Amanda) Tong as they discuss the article "Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240426.766271

This week, please join author Prakriti Gaba as she discusses the article "Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With and  Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240422.957293

This week, please join author Gilles Montalescot as he discusses the article "Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment−Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240412.432949

This week, please join author Hanjoong Jo, editorialist M. Luisa Iruela-Arispe, and Associate Editor Charles Lowenstein as they discuss the article "HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells," as well as the Editorial "Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle."

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240408.470208

This week, please join author Nicholas Mills as he discusses the article "Machine Learning for Myocardial Infarction Compared With Guideline Recommended Diagnostic Pathways.

For the episode transcript, visit: 

https://www.ahajournals.org/do/10.1161/podcast.20240329.877789

This week, please join author William McIntyre, Editorialist Christian Ruff, and Associate Editor Shinya Goto as they discuss the article "Direct Oral Anticoagulants for Stroke Prevention in Patients With Device-Detected Atrial Fibrillation: A Study-Level Meta-Analysis of the NOAH-AFNET 6 and ARTESiA Trials."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240322.70604

This week, please join author John Triedman and Associate Editor Gerald Greil as they discuss the article "Pediatric ECG-Based Deep Learning to Predict Left Ventricular Dysfunction and Remodeling."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240315.583656

This week, please join author Kieran Docherty and Associate Editor Justin Grodin as they discuss the article "Effect of Dapagliflozin Versus Placebo on Symptoms and 6-Minute Walk Distance in Patients With Heart Failure: The DETERMINE Randomized Clinical Trials."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240306.916294

This week, please join author Samir Kapadia and Editorialist Neil Kleiman as they discuss the article "Concomitant Left Atrial Appendage Occlusion and Transcatheter Aortic Valve Replacement Among Patients With Atrial Fibrillation."

For the episode transcript: https://www.ahajournals.org/do/10.1161/podcast.20240301.133854

This week, please join author Josep Rodés-Cabau and Associate Editor Dharam Kumbhani as they discuss the article "Transcatheter or Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis and Small Aortic Annulus: A Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240226.780348 

This week's podcast features a panel discussion. Please join authors Masahiro Natsuaki, Myeong-Ki Hong, and Robert Storey, as well as Associate Editor Stefan James as they discuss the Original Research Articles "An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial" and "Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial" and the Editorial "Antiplatelet Therapy After PCI: The Art and Science of De-Escalation."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240220.712469

This week is Circulation's annual Go Red for Women issue. Please join Special Issue Editors Sana Al-Khatib and Mercedes R. Carnethon as they discuss the issue. Then they interview authors Jaime Kitt and Shanshan Sheehy as they discuss the articles "Cardiac Remodeling After Hypertensive Pregnancy Following Physician-Optimized Blood Pressure Self-Management: The POP-HT Randomized Clinical Trial Imaging Substudy" and "Perceived Interpersonal Racism in Relation to Incident Coronary Heart Disease Among Black Women."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240212.130685

This week, please join author Brendon Neuen and Editor Sandeep Das as they discuss the original research article "Estimated Lifetime Cardiovascular, Kidney, and Mortality Benefits of Combination Treatment With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Nonsteroidal MRA Compared With Conventional Care in Patients With Type 2 Diabetes and Albuminuria."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240205.184727

We have a panel discussion with authors Albert Wiegman and Frederick Raal and Editorialist Raul Santos as they discuss the original research articles "Evinacumab for Pediatric Patients With Homozygous Familial Hypercholesterolemia" and "Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/110.1161/podcast.20240129.812328

This week, please join author Geert-Jan Geersing he discusses the article "Safety of Switching From a Vitamin K Antagonist to a Non–Vitamin K Antagonist Oral Anticoagulant in Frail Older Patients With Atrial Fibrillation: Results of the FRAIL-AF Randomized Controlled Trial."

For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240122.313687