The Lab Report

The gut microbiome is more than just bacteria. It encompasses all organisms and genetic material including yeast, viruses, and archaea. It is a common belief that yeast in the GI tract needs to be eradicated. But not so fast.

In this episode, we focus on the mycobiome. We examine the dual roles of commensal and pathogenic yeast species within the GI tract, exploring how they influence immune signaling, metabolic function, and mucosal integrity. We also discuss emerging evidence linking fungal dysbiosis to conditions such as Inflammatory Bowel Disease, cancer, and systemic inflammation.

If you’re in...

The Thanksgiving holiday is more than just family, friends, food, and football. It is an opportunity to be reminded of the importance of gratitude. Although being thankful seems like just a nice moral platitude, gratitude interventions are shown to have surprisingly important clinical implications for our health.  

On today’s episode, we talk Thanksgiving ‘fun facts,’ gratitude interventions, and strategies to combat holiday season stress and weight gain.  

Today on The Lab Report: 

Gut motility may be the most important and least discussed aspect of health. One vital part of gut motility is the Migrating Motor Complex. The Migrating Motor Complex (MMC) is the gut’s “street sweeper,” clearing food and bacteria to maintain intestinal homeostasis between meals. In this episode, we review its physiology, regulatory mechanisms, and clinical relevance – from SIBO to functional GI disorders – highlighting why this cyclical motility pattern matters for patient care.

Today you’ll meet the migrating motor complex: your gut’s built-in street sweeper that clocks in when you’re not eating. This behind-the-scenes cleaning cycle i...

The microbiome continues to be viewed as a cornerstone of health, whether we are discussing the gastrointestinal tract, cardiovascular risk, immune dysfunction, and even cognitive health. One major contributions of the microbiome to our global health is in the production of short-chain fatty acids. Primary among these products is a compound known as n-butyrate. N-butyrate has profound roles, not only in our gut, but throughout our entire body. What are all the impacts of n-butyrate, and how do we foster an adequate supply of it? These are but some of the questions we discuss on today’s Lab Report.

Based on recent research, the term ‘dysbiosis’ is no longer a simple black-and-white diagnosis of a gut imbalance. The scientific understanding of a healthy microbiome is evolving. It’s no longer just about the laundry list of organisms present, but rather about their functionality for health and disease.

In today’s episode, we unpack the term ‘dysbiosis.’ Join us to rethink what it means to have a healthy microbiome, the utility of novel algorithmic scoring, and how a deeper understanding of this complex ecosystem is opening doors to more targeted diagnostics and therapeutics.  

Today on The Lab Report...

Like Hippocrates said, “All Disease Begins in the Gut.” Here in functional/personalized medicine, stool testing is an important tool to help get to the root cause of chronic conditions or to optimize health. Given its vital role in clinical practice, choosing the right stool test becomes paramount and being mindful of the information you are seeking is key.

In today’s episode, we're taking the conversation deeper, refocusing on why studying the microbiome is so critical. This episode redefines the clinical utility of Genova's stool tests, giving you the insights you need to make informed decisions and ge...

Heat Shock Proteins (HSPs) are often called molecular chaperones. These crucial proteins spring into action when cells are under threat from environmental stressors, toxins, inflammation, and oxidative stress.

Join us as we uncover how heat shock proteins function as the cell’s microscopic repair crew. Discover how this fundamental biological mechanism not only protects our cells from daily stresses but also holds promising clues to treating age-related illnesses like cancer and neurodegenerative diseases.

Today on The Lab Report:

Licorice root is a time-honored herbal remedy with a sweet side. Beyond its role in teas and tonics, licorice root has been used for centuries to support digestion, ease respiratory illnesses, and calm everyday inflammation. It is well- known for its synergistic effects with other herbal therapies.

Join us as we talk about how licorice root can fit into your wellness routine, the traditions behind its medicinal use, and simple ways you can explore these benefits safely.

Today on The Lab Report:

Mitochondrial dysfunction may be one of the most important topics in the area of personalized and preventative medicine to date. Thousands of articles have been published on the nature of how mitochondria become damaged and what that means for health, longevity, and aging. On today’s podcast, we take a deep dive into the triggers for mitochondrial dysfunction and what clinical conditions are related to damaged mitochondria.

We also discuss how to arm your arsenal with everyday items to help stability, protect, and maintain our mitochondria. We also discuss how other systems within and outside the cell ar...

Eggs are one of the most widely-consumed, and underappreciated, foods in the human diet. Long regarded as a nutritional powerhouse, eggs are rich in high-quality protein and essential nutrients that are key for health. In fact, eggs are considered the best complete protein – meaning they contain all 9 essential amino acids. But for decades, eggs were caught in the crossfire of the cholesterol debate.

In today’s episode, we’ll explore what current research says about the relationship between eggs and heart health, and whether concerns about dietary cholesterol still hold up. We’ll also discuss the role of eggs...

Stool testing technology has advanced rapidly in recent years, with newer methods like PCR and whole-genome sequencing offering faster and more precise insights into the gut microbiome. These innovations have transformed how clinicians approach gut health, allowing for more targeted interventions. However, older technologies—such as microscopy, culture, and enzyme-based assays—still play a valuable role. These methods provide functional insights that molecular tools may miss, such as direct observation of parasites or assessment of digestive markers. The most comprehensive labs recognize that no single method gives the full picture. Instead, combining the strengths of both modern and traditional tech...

N-acetylcysteine, or NAC, plays an important role in the body when it comes to combating oxidative stress. As a precursor to make glutathione, NAC has been used for decades both as an acute medication and as an over-the-counter supplement. Recently, the line between medication and supplement has been blurred and is now being debated.

Today we talk all about N-acetylcysteine - the ways NAC is used and its importance in health and disease.

Today on The Lab Report:

Turmeric is a spice with ancient origins. You’ve seen it in smoothies, teas, curry, and supplements.  Known for its bright yellow color, it has been used for centuries to support whole-body wellness. From inflammation and joint pain to brain and heart health, in this episode we break down what the science says about turmeric and its main constituent curcumin.

Join us as we explore turmeric’s long-standing role in health and wellness and zoom in on curcumin. We break down what the science says about curcumin’s therapeutic potential, how it’s absorbed, and whether supplementation is worth...

There’s a lot of buzz around the topic of longevity. One might argue that every aspect of functional and integrative medicine promotes longevity – which is true. We’re not merely looking to lengthen lifespan we want to promote a HEALTH span. With that in mind, data is compelling. There’s one metric that is often overlooked which happens to be the greatest predictor of longevity: VO2 max.

Join us as we dive deep into how VO2 max impacts health, longevity, and overall well-being. We’ll discuss the science, how to measure it, and how to improve this cruci...

As we enter the summer season, many of us will spend countless hours outdoors. We often discuss tick awareness and tick-borne illness, but one tick in particular is getting a lot of press these days. In case you needed another reason to be mindful of ticks, today we discuss Alpha-gal Syndrome.

In today’s episode we explore the science behind alpha-gal syndrome – a rare and serious allergy to red meat and other mammal products triggered by a bite from the Lone Star Tick. Tune in to learn how to recognize symptoms and why this syndrome is spreading acro...

Tinnitus—the phantom ringing, buzzing, or hissing that affects millions. For those patients who suffer with this debilitating condition, it is frustrating to find any relief. For those clinicians trying to treat it, the causes are so multi-faceted, and the treatments seem to be lacking.  

Today we break down the physiology of hearing, what can go wrong in the auditory system, and the many potential causes of tinnitus, from noise exposure to neurological conditions. We also examine current treatment options, emerging therapies, and what the latest research says about finding relief. Whether you're a sufferer or just curi...

Dr. Laura James is a board-certified naturopathic oncologist who has been working with cancer patients for over 20 years. She helps patients who are recently diagnosed with cancer get through the intense steps of conventional treatment – surgery, chemotherapy, and radiation – using natural means like nutrition, herbs, gentle movement, and stress management.

In today’s episode, we hear Dr. Laura James discuss her balanced viewpoint on the use of natural therapies in combination with conventional treatment to support cancer patients. Through supplement streamlining, nutritional and botanical recommendations, and lifestyle counseling, her expertise can help you feel better through treatment and be...

Are ORAC scores the secret to superfoods—or just marketing fluff? In this episode, we break down what ORAC (Oxygen Radical Absorbance Capacity) really measures and why it stirred up so much controversy. The USDA pulled the plug on publishing the data, but does the concept still hold any value in nutrition science today?

In today’s episode, we dive into a myth-busting conversation that explores the science of ORAC, the skepticism, and the truths about antioxidants and health.

Today on The Lab Report:

Inflammation is your body’s way of protecting itself from infection, injury, or other insults. Chemical signaling molecules called ‘eicosanoids’ are responsible for creating pain, heat, swelling, and redness. Eicosanoids are made from fatty acids, or dietary fats. We’ve all heard of fish oil and omega-3s being important when it comes to lowering inflammation. But why?

In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’

Today on The Lab Report:

If you are worried about keeping your bones strong, there’s more to the story than taking calcium supplements. Vitamin D and vitamin K work together to support strong, healthy bones. Vitamin D helps your body absorb calcium from food, which is essential for building and maintaining bone density. But without enough vitamin K—particularly vitamin K2—that calcium might not end up where it's needed. Vitamin K2 activates proteins that help direct calcium into bones and teeth while keeping it out of soft tissues like arteries. In other words, vitamin D gets the calcium in, and vitamin K makes...

Zombie cells, scientifically known as senescent cells, are damaged or aged cells that refuse to die when they should. Instead, they linger in the body, releasing harmful chemicals that can trigger inflammation and accelerate aging. These cells have been linked to a range of age-related diseases, including arthritis, Alzheimer’s, and even cancer.

Dive into the eerie world of 'Zombie Cells' on our latest episode! Uncover how these undead cells wreak havoc in our bodies and what cutting-edge research reveals about their role in aging and disease.

Today on The Lab Report:

Such a random topic – gray hair? The technical term for hair graying is canities – again, what a strange word. Who knew? The basic physiology of hair growth and coloration is not something we really think about, but your hair can be a reflection of underlying health or disease. We often talk about the aging process as a marker of oxidative stress -So too with your hair.

In this episode, we dive into the science of graying hair. From melanin loss to genetics to some surprising lifestyle connections, we separate fact from fiction and uncover the truth about your...

Hiccups- that annoying and at times, painful reflex that sneaks up on you when you least expect it, and sometimes refuses to leave. But what are they really? Is there an evolutionary reason we’ve developed this reflex? When should you be concerned? Can we prevent them?

In this episode, we break down the pathophysiology of hiccups (yes, there’s real science behind it) Knowing the science of why they occur, we can separate fact from fiction on how to cure them. From medical insights to strange home remedies, we’re getting to the root of the world’...

Akkermansia muciniphila has been getting tons of great press recently. It’s a bacterium in the gut microbiome that thrives by supporting mucin production. However, its potential to enhance metabolic health and support weight management has paved the way for innovative probiotic solutions – which is exactly what a company called Pendulum has done! Pendulum’s products are backed by cutting-edge research showing clinical efficacy.

Today we speak with Christina O’Connor, registered dietician and Senior Healthcare Account Manager at Pendulum Therapeutics. Christina breaks down all the latest research on Akkermansia muciniphila and how optimizing levels can lead to great...

Advanced technologies and personalized approaches have been the hallmark of what we do here at Genova Diagnostics. We are frequently asked how this testing can be applied in pediatrics. Our testing is widely used to help empower parents to get to the root cause of some common childhood concerns. But there are some caveats to consider when interpreting results.

Every child is unique – so why shouldn’t their healthcare be? In this episode, we dive into the world of personalized medicine for children and how Genova’s cutting-edge testing can unlock better health outcomes for kids.

Toda...

We all know sugar isn’t great for our health. But is all sugar created equal? In this eye-opening podcast, we speak with the team from RxSugar. Their company creates and promotes a healthy sugar called allulose. Yes, a healthy sugar!

Dr. Rick Johnson is a leading researcher on the hidden dangers of sugar. He discusses the impact of how sugar and fructose can hijack your cravings, fuel inflammation, and contribute to chronic disease. We also meet former Google Exec Neil Gyte. His personal journey toward metabolic health found him crossing paths with the science team at Rx...

Garlic isn't just a kitchen staple—it’s a natural powerhouse of health benefits! Packed with antioxidants and sulfur compounds like allicin, garlic supports heart health by lowering blood pressure and cholesterol, strengthens the immune system, fights inflammation, and so much more. With its antibacterial and antiviral properties, garlic has been used for centuries as a natural remedy for colds, infections, and overall wellness.

Whether eaten raw, cooked, or taken as a supplement, garlic is a simple yet powerful way to boost your health naturally. Join us as we discuss this unsung herbal hero.

Today on T...

Longevity isn’t about adding years to your life- it’s about adding life to your years!  We know there are many variables to health such as diet, movement, sleep, social connection, fresh air and sunlight. Each are important but some aren’t easily measured.

The Roseto Effect reveals the surprising power of tight-knit communities, social bonds, and old-world traditions in shaping our health. Join us as we tell the story of a small town in Pennsylvania called Roseto. Can community be the ultimate medicine? 

Today on The Lab Report:

Ever wonder what happens when your voice suddenly decides to take a vacation? In this episode, we explore the mysterious condition of laryngitis. From causes to symptoms, we can help you discover the best ways to recover and protect your voice.

Whether you're dealing with laryngitis now or just curious about how it works, this episode will give you the answers you need. Tune in for all the insights into a silent struggle!

Today on The Lab Report:

When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you!

On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas.   

Today on The Lab Report:

As the days get shorter and the air turns crisp, cold and flu season sneaks in bringing sniffles, coughing, fatigue, and fever. It’s a time when germs spread easily, and our immune systems face a tough challenge. When you add holiday stress in the mix, it becomes even more important to boost your defenses, and optimize your immunity.

In today’s episode, we offer tips to help you unlock your body’s natural defenses as we try to navigate cold and flu season. This podcast has everything you need to stay ahead of seasonal sickness so you ca...

The holiday season is a time of joy, connection, and celebration – but to be honest, it can also be incredibly stressful. Between hosting dinners, finding the perfect gifts, managing finances, and navigating family dynamics, it’s easy to feel overwhelmed. The good news? You’re not alone and there are ways to reclaim the magic of the season without losing your sanity.

In today’s podcast, we dive into the science of stress and how the vagus nerve holds the key to calm. Discover how breathwork, mindfulness, and gratitude can transform your holiday experience, helping you stay grounded...

Where to begin? It’s been a few weeks since you’ve heard from us – thank you so much for your amazing support and patience. As you may know, Hurricane Helene brought devastation to western North Carolina, eastern Tennessee, South Carolina, Georgia, and Florida. Genova Diagnostics is headquartered in the heart of Asheville, North Carolina. With that, it’s been a challenging few weeks. But the heroic efforts of many, and the resilient spirit of our team have us back up and running. Genova continues to support our local community- many of whom are still struggling and have lost everythi...

Gastroesophageal reflux disease (GERD), or heartburn, is incredibly common as is the use of stomach acid suppressing medication. But what if there is far more to the story than stomach acid? There are many other factors to consider in a patient with heartburn. We are going to dive into the physiology of gastric acid, gastric hormonal signaling, and a slew of medications and foods that might be the real culprit. Are PPI’s over prescribed? Are we missing the picture? Tune in to find out.

In today’s episode, we tackle some burning questions about GERD and try...

Occasionally, there are new and novel things introduced into the functional medicine and biohacker space that catch our attention. Lately, you might have heard a lot of people talking about the amazing health benefits of “nootropics,” but what are they? Coming from the name of the Greek word Nous (meaning “mind”), nootropics are medicines designed to improve cognitive function and protect the brain. Many of us could use a healthy dose of cognitive support to help us through our busy lives, but what is the truth about nootropics and where can we find them?  

In today’s episode, we...

Ok, we know what you’re thinking…. Artichokes? Really? Yes really. It may seem a bit out of left field, but you’d be surprised at the many health benefits from either eating artichokes or taking an extract supplement. As a vegetable, it contains fiber, vitamins, minerals, and antioxidants. Extracts made from artichoke leaves, stems, and roots have been used as nutraceutical agents to support the GI tract, liver, and cardiovascular system. But why?

In this episode, we peel back the layers of the artichoke – a very mysterious plant indeed.  Is it possible to boost your health with arti...

Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyperreactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused. 

In today’s episode, we focus on the ro...

The gut microbiome harbors trillions of commensal organisms which play a central role in our health. This community is sometimes referred to as our hidden metabolic organ due to its immense impact. Our diet and lifestyle play an important role in feeding the microbiome and keeping the colonies in balance. Should we be concerned if any one bacterial colony overgrows?

Today we discuss the commensal bacteria Desulfovibrio. Since this genus of bacteria can reduce sulfate and make hydrogen sulfide gas, overgrowth can have clinical implications. Listen in for more information on why you should care and what...

There are a lot of terms bantered about in the biohacker and longevity space. With that, you’ve likely heard of mTOR – mechanistic (mammalian) target of rapamycin. But what exactly is it? mTOR is a key regulator in your body’s metabolic and growth processes. It integrates various signals, including nutrients and growth factors, to control processes like protein synthesis, autophagy, and lipid metabolism. Because it regulates growth, dysregulation of mTOR has been implicated in various diseases, including cancer.

In today’s episode, we simplify the science behind mTOR – mechanistic target of rapamycin. This crucial enzyme may be the key...

Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.

Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important an...

Many of us have heard of glutathione and understand that it is a powerful antioxidant – but why? What is it? How does it work? Understanding the mechanisms of this crucial molecule can help you fully grasp its importance. Oxidative stress and the damage of free radicals underlie the aging process and many chronic conditions. There’s no greater tool to combat oxidative stress than glutathione.

In today’s episode, we break down the science of glutathione and redox reactions. You will learn how glutathione works, how to support optimal levels, and how it connects to the methylation cycle...

Creatine is a powerhouse supplement known for enhancing muscle strength, endurance, and recovery. By boosting ATP production, it fuels muscles during intense workouts, leading to greater gains and faster progress. Beyond its skeletal muscle benefits, creatine supports cognitive function, fertility, sight, hearing, and just about every process in the body.

Today we discuss creatine and its many health benefits. Whether you're an athlete striving for peak performance or someone simply looking to improve overall health and vitality, consider fueling your potential with creatine.

Today on The Lab Report:

Dr. Bill Rawls was a practicing OB/GYN physician for decades before his health began to suffer and he was faced with the limitations of modern medicine. Embarking on his own health journey, he dove headfirst into holistic and herbal therapies and found ultimate wellness. Dr. Rawls now teaches and writes extensively about the power of herbal medicine. He’s written several books including Suffered Long Enough, Unlocking Lyme, and his latest book The Cellular Wellness Solution. Dr. Rawls even started his own herbal supplement and wellness company called Vital Plan.

In today’s episode, Dr. Bill Rawl...

In the world of athletic performance, there are plenty of health experts. But none like Ian Craig. Ian Craig takes a holistic and very personalized approach. With his joint academic backgrounds in exercise physiology and nutritional therapy, and a long successful career as a British middle-distance runner and coach, he’s been developing the concept of integrative sports nutrition for the past 20 years.

Today we speak with Ian Craig who lays out the case for personalized and holistic care when it comes to optimizing athletic performance. Through his Centre for Integrative Sports Nutrition in Scotland, he’s been...

Artificial intelligence and machine learning is being leveraged in every facet of society to improve efficiency and drive innovation. Healthcare is no different. Language models, algorithms, machine learning, and more are being developed and used to help with education, behavior change, administrative tasks, predictive risk assessments, and at times, disease diagnosis.

In today’s episode, we discuss areas where the healthcare industry is harnessing artificial intelligence. With such powerful technology at our fingertips, it is always important to take a pause to debate the exciting capabilities but also its limitations and biases.

Today on The La...

Is it possible to be drunk without drinking alcohol? Actually, yes. There is a condition called auto-brewery syndrome whereby an imbalance in your gut microbiome can ferment carbohydrates to create alcohol. Blood alcohol levels can get surprisingly high. Though this condition is thought to be rare, it might just be underdiagnosed. Patients are dealing with legal ramifications, social stigmas, and disbelief by friends, family, and physicians.

Today we introduce the topic of auto-brewery syndrome to raise awareness that your gut microbiome can produce alcohol. We discuss how it occurs, how to diagnose it, and some strategies to...

Food labels can be very confusing. In fact, many of us completely ignore them. If you look at the ingredients in many processed foods, you’ve probably tried to pronounce some of the chemical compounds listed in the ingredients. The food industry adds chemicals to food to either enhance flavor and color, or to preserve shelf life. There are thousands of accepted food additives and some may have important health implications.

In today’s episode, we discuss just a few additives you might want to keep an eye out for next time you go to the grocery stor...

Shakira Niazi is the founder of Basil Seed Works – an organic basil seed product line featuring the superfood ZenBasil. As a refugee from war-torn Afghanistan who was later raised and educated in the US, Shakira’s path to becoming an entrepreneur is remarkable. Although she’s known for her work with Vita Water – helping to solve the world water crisis and providing water points to poor villages around the world, her current focus is to bring basil seeds from the Far East to the Western world. Basil seeds are a natural source of fiber, omega-3 fatty acids, vitamins, minerals, and anti...

Dr. Stephanie Venn-Watson dedicated her life to public health and veterinary epidemiology. In studying dolphins, she discovered the first essential fatty acid to be found in over 90 years – C15:0 (pentadecanoic acid). Dr. Stephanie’s discovery and further research on C15:0 has uncovered some amazing cellular health benefits and significant potential for disease prevention. With this knowledge, Dr. Stephanie pivoted and founded fatty15 - a company that produces the world’s first, and only science-backed, patented C15:0 supplement.

In today’s episode, we speak with Dr. Stephanie Venn-Watson about her latest research into the newly discovered essential fatty acid C15...

Methylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In a previous episode, we introduced the topic of methylation and the basics of this biochemical reaction.  However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance.

Today, we dive a bit deeper into the biochemistry of methylation and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Gen...

We are honored to welcome Dr. Casey Means back to the show. She is not only a passionate advocate for metabolic health, but also a voice of reason amidst a broken healthcare system, a profound champion spreading the message of connectedness and fearlessness, and lastly a dear friend. Dr. Means’ new book “Good Energy – The Surprising Connection Between Metabolism and Limitless Health” is available now anywhere books are sold.

In this episode, we talk to Dr. Casey Means about her new book “Good Energy” which outlines how to connect the dots in healthcare, the critical importance of metabolic he...

The word ‘methylation’ has become somewhat of a buzz word in functional and personalized medicine. We’ve mentioned it several times throughout many episodes of The Lab Report – hard to avoid since it’s involved in just about every biological process.

In today’s episode, we finally hit the topic of methylation head on and dive into the methylation cycle itself. What is it? Why should you care? Although biochemistry can be intimidating, listen as we simplify and demystify the steps involved. You may find it helpful to refer to a Methylation Pathway Chart while listening to this one! Duration: 00:32:48

Everest Goldstein is a board-certified Psychiatric Nurse Practitioner who is also certified in Functional Medicine and has an extensive background in integrative wellness interventions. She deeply cares about her patients and devotes her time to working closely with each of them to address their individual needs. Knowing the importance of the brain-body connection, Everest addresses the body as a whole to optimize health and wellness.

In today’s episode, we dive into the root causes of mood disorders and psychiatric illness with Everest Goldstein. Everest discusses how nutrition, diet, and lifestyle can contribute to mental health and we...

Berberine is an alkaloid compound that can be extracted from several plants. It is a widely used supplement in personalized medicine and is also beginning to get some traction within the conventional medicine space. Berberine is mainly used in the GI tract for its antimicrobial effects, but as it relates to gut health, that’s just the tip of the iceberg. What is even more fascinating is berberine’s vast systemic metabolic influences.

In today’s episode, we dive into the wide array of berberine’s important effects. Not only on the gut, but also on detoxification systems...

For decades Dr. Nigma Talib has been helping patients using her clinical expertise in naturopathic medicine. Her contributions to the field are recognized globally. Dr. Nigma has authored best-selling books such as “Reverse the Signs of Ageing” and “Younger Skin Starts in the Gut.” She was one of the first pioneers to introduce vitamin supplements in the fashion industry and she’s responsible for the radiant, glowing skin of some of Hollywood’s most famous faces.

In today’s episode, we are honored to meet Dr. Nigma Talib. We discuss her holistic approach to health and learn her skincare t...

Taylor Morgan Christie is a board-certified Physician Assistant, a registered dietitian nutritionist, and she’s double board certified in functional medicine through IFM and IFNA. So, it should come to no surprise that she can basically riff on any topic we throw at her. However, she has a special passion for treating thyroid disorders and helping her patients find whole wellness. She’s spent over a decade studying and mastering her clinical approach and today we learn all about it.

On today’s episode, we talk all things thyroid with Taylor Morgan Christie, PA-C. Thyroid physiology, symptoms, medica...

If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry?

In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and...

Ok, well…. Today’s episode is a bit unique…. The intention was to discuss the important benefits of a trace mineral called boron. It is an important mineral, make no mistake. But, as we started recording, we got bored. Turns out talking about boron is kind of boring! So, we do hit the boron highlights, but then, in typical Patti & Michael fashion, we veer off into debate and discussion. The topic became the danger of misinformation by health influencers and how to remain skeptical.

Today on The Lab Report:

Genova’s nutritional testing offers precision results and personalized recommendations to create a nutritional treatment plan for optimal health and wellness. But for patients and clinicians, this can seem overwhelming when there is a significant amount of nutritional need. In addition to dietary counseling, clinicians often reach for supplements. VitaminLab is a premier supplement company in Canada that can customize results from the NutrEval and Metabolomix+ into as few pills as possible to help with patient compliance. Dr. Lydia Thurton is a naturopathic physician who works with clinicians through VitaminLab to help them through the process.

In to...

Cayenne pepper, derived from the Capsicum annuum plant, is a fiery herb renowned for its intense heat and vibrant flavor. It contains a compound called capsaicin which is not only responsible for its spicy punch, but also numerous health benefits. Beyond its culinary uses, cayenne is highly regarded for its medicinal properties in gut health, pain relief, and even cardiometabolic disease.

In today’s episode, we turn up the heat as we delve into the fiery world of cayenne. From its origins to its culinary and medicinal uses, we’ll uncover the secrets and surprising health benefits of t...

Genova’s Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine.

Today is part 3 of our series where we chal...

Foods come in and out of favor all the time. Eggs are good for you… no wait, they are bad… nope, good again – let’s not even discuss butter! There are many disease correlations related to specific foods and literature continues to evolve. One such focus is on red meat and its correlation to cardiovascular disease.  But why? Is all red meat bad? Can you eat red meat and not increase heart disease risk? What about it should cause concern? Interestingly, the answer lies in the microbiome’s ability to metabolize the carnitine in red meat into a metabolite called trim...

Patti & Michael are on the road! We recorded this unique episode from the Genova Diagnostics booth as a sponsor of the Metabolic Health Summit 2024 in Clearwater Beach, Florida. This conference brings together cutting-edge research, world-class speakers, and the leading experts in metabolic health. As you can imagine, Genova’s testing is a key element in getting to the root cause of metabolic disfunction and optimal health. The personalization of our testing and results can help guide therapeutic modalities that may not be so obvious.

In today’s episode, you’ll hear Patti & Michael recorded live from the Genova...

Dr. Bill Rawls was a practicing OB/GYN physician for decades before his health began to suffer and he was faced with the limitations of modern medicine. Embarking on his own health journey, he dove headfirst into holistic and herbal therapies and found ultimate wellness. Dr. Rawls now teaches and writes extensively about the power of herbal medicine. He’s written several books including Suffered Long Enough, Unlocking Lyme, and his latest book The Cellular Wellness Solution. Dr. Rawls even started his own herbal supplement and wellness company called Vital Plan.

In today’s episode, Dr. Bill Rawl...

Dr. Taz Bhatia is a conventionally trained physician who has always been way ahead of her time. For years she’s been combining the best of modern science with eastern medical wisdom to help patients get to the root cause of chronic disease. As one of the OGs in functional and integrative medicine, Dr. Taz has become a national social media influencer, author, speaker, podcaster, television star, and go-to expert in women’s health. Her latest book “The Hormone Shift” offers patients the tools they need to navigate life’s hormone changes with ease.

In today’s episode, we...

Genova’s new Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine.

Today is part 2 of our series where we c...

Hormones are complicated! The body makes dozens of hormones that influence each other. Fine-tuning that full hormonal symphony can lead to significant symptom improvement and well-being. Genova’s testing can help and the new Endo+ Profile is a great place to start. With this latest product upgrade, we’ve spent almost 2 years scouring the literature for the most up-to-date clinical information to help guide clinicians. However, while we were knee-deep in research and literature, we found ourselves with conflicting messaging and realized the echo chamber in personalized medicine might need to be re-examined.  

In today’s episode, we begin...

The subject of men’s health is often not discussed. A lot of men don’t proactively seek help for health concerns nor even want to admit there’s a problem. Well, today we’re going to change that. Ali Gilbert is a nationally recognized coach, lecturer, personal trainer, and expert in men’s health. Her Silverback Coaching programs help men from all walks of life, from CEOs to professional athletes and regular dads get to optimal physical and mental health.

Today we meet Ali Gilbert and hear about her passion to help men get jacked, look great nake...

When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you!

On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas.   

Today on The Lab Report:

The body makes dozens of hormones that affect our health every day -sex hormones, thyroid, cortisol/stress hormones, melatonin etc. When hormones are out of balance, it can lead to symptoms like hot flashes, low libido, weight fluctuations, hair or skin changes, and many more. These symptoms can overlap since all hormones influence each other. That means, to get a full picture of hormonal health we need a broader lens.

Listen in today as we discuss Genova’s Endo+ Profile – The first of its kind. Endo+ is a modular panel of testing that offers the unique ability to a...

William Branum is a decorated Navy SEAL veteran with 26 years of active-duty service. Since leaving the military, William has dedicated his life to helping others through mentorship, coaching, speaking, and entrepreneurship. William’s expertise has been sought after by organizations ranging from small universities to Fortune 500 companies. He draws on his experiences to provide practical advice on how to cultivate a leadership style that inspires and motivates others, and how to develop the resilience needed to succeed in challenging environments. William founded the company ‘Naked Warrior Recovery’ to develop premium CBD products to support mental and physical recovery, through which...

Magnesium is a mineral that is crucially important to hundreds of biochemical reactions in our body. With gradual changes in soil, food processing, and the Standard American Diet, many of us just are not getting enough. So, what do we do? Dr. Robert Fredrickson has recently released a book all about this issue: Magnesium Answers: Unlocking the Secrets of Magnesium. As a functional medicine practitioner, he spent his career educating patients and doctors, but he also has a background as a product educator for major supplement companies. With that, Dr. Fredrickson is in a unique position to help us...

Thanksgiving is a time to be mindful and reflect on our many blessings. During the holiday, many of us enjoy dinner with family and friends without stopping to consider the nutritional aspects of traditional dishes. Today, we discuss the important biochemical and nutritional benefits of Thanksgiving dinner items. We also talk about dealing with the stress of the holidays and the many reasons we are grateful.

Today on The Lab Report:

The immune system works tirelessly to maintain health and well-being. This formidable defense mechanism is comprised of a vast array of cells, tissues, proteins, and molecules that work together to identify and neutralize foreign invaders. The inflammation that ensues can be recognized by redness, pain, swelling, and heat. In order for this process to take place, the body needs to be able to identify what is ‘friend or foe’. But how? There are certain molecular patterns that our immune system recognizes as part of this surveillance and recognition. Some patterns are associated with pathogens - “pathogen-associated molecular patterns” (PAMPs). Others a...

When it comes to changing the way the world views mental health, one voice remains consistent, science-based, empathetic, and passionate. That’s Brendan Vermeire. Brendan is dedicated to advancing the science of mental health dysfunction through his research, teaching, writing, and speaking. Here in functional and precision medicine, we are always looking for the root cause of any dysfunction. However, Brendan reminds us that mental health can have several root causes that need to be addressed and many of us are falling short when it comes to treating patients with mental illness.

In today’s episode, we meet...

The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse’ of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic.

In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don’t need to be treated.  

Tod...

When it comes to assessing the microbiome, technology continuously evolves. With that, our understanding of the microbiome deepens. There is a lot of confusion out there regarding technology. Companies use marketing spin to lead you to believe the newest is the best when in fact, every technology has its strengths and weaknesses. No one method can capture the entire dynamic of the microbiome. Here at Genova, we use many methods to give you the most complete look at overall gut health.

Today we simplify the science behind laboratory assays used to study the microbiome – culture, qPCR, metagenomics, an...

Many clinicians learn about functional medicine and get very excited to start but just can’t figure out how to fit it into their practice or make the big leap away from conventional, insurance-based practice models. Dr. Michael Hilts figured it out. Dr. Hilts found out about the “Direct Primary Care” model which allowed him to fulfill his dream of bringing the best healthcare possible to his patients. In addition, his innovative strategies with outside imaging centers, laboratories, and pharmacies bring down the cost to patients in an almost unbelievable way! Could this be the answer to fixing our curren...

When it comes to sex hormones, progesterone is the unsung hero. It is actually the precursor to even making estrogen and testosterone. But progesterone is not just a precursor hormone. It is vital for maintaining pregnancy, helps with mood and sleep, works to help regulate the body’s water stores, and so much more.

In today’s episode, we unpack all of the important functions of progesterone, break down its many fates of metabolism, and talk about ways to optimize your hormonal balance.  

Today on The Lab Report:

Have you ever said to yourself “Hey, I’m doing pretty good for my age”? Well, today’s episode will change everything you thought you knew about aging. Dr. Jeffrey Gladden is not only a renowned expert in longevity medicine but also a cardiologist, author, international speaker, and host of The Gladden Longevity Podcast. His personalized approach, ground-breaking therapies, and team of experts help guide you on a journey toward optimal health, longevity, and performance. Dr. Gladden’s latest book “100 is the New 30 – How Playing the Symphony of Longevity Will Enable Us to Live Young for a Lifetime,” outlines a roadmap to bou...

When people hear the word ‘cannabinoid’, what usually comes to mind is marijuana (also known as cannabis) or CBD oil (cannabidiol). But did you know, the body creates its own natural cannabinoids using the endocannabinoid system? This endocannabinoid system is a mysterious and complex interplay of chemical messengers throughout the brain and body which in essence contributes to our body’s homeostasis. It regulates a broad array of physiological processes including pain, mood, sleep, inflammation, appetite, and more. Rather than relying on marijuana or CBD products, Dr. Joe Feuerstein teaches that there are ways to boost the endocannabinoid system natura...

Many of us think of adipose tissue as just a place to store excess fat to be used for energy. However, adipose tissue is very biologically active and secretes some important hormones and mediators called adipokines. These messengers help regulate glucose and lipid metabolism, control hunger, and affect insulin levels. That being said, ALL of our hormones work together like a symphony – cortisol, thyroid hormones, sex hormones, and don’t forget the adipokines.

In today’s episode, we discuss important bioactive messengers created by our fat tissue (leptin and adiponectin), how they affect us systemically, and strategies to opt...

The commensal bacteria in the gut microbiome are responsible for so many important functions. Their influence is far-reaching as it relates to overall health. Research shows us that the more diverse that community of bacteria is, the more beneficial it is to systemic health. But what does diversity mean and how do we measure it? There are many calculations used when it comes to diversity of the microbiome, and they can sometimes give differing information. It’s important to understand what’s being measured in order to clinically correlate the result.

In today’s episode, we discuss the in...

The NutrEval Profile is Genova’s most comprehensive nutritional assessment providing a framework of core nutrients in the areas of antioxidants, B-vitamins, digestive supports, essential fatty acids, and minerals. This functional evaluation is aimed at assessing nutrient insufficiencies and biochemical individuality. In the Medical Affairs department, we are privileged to speak with clinicians every day to interpret test findings in clinical context, answer general questions about testing, and dive into the latest literature to expand our understanding too.

On today’s episode, we address the top 5 most frequently asked questions about the NutrEval. Although we are focusing on the...

There are very few key opinion leaders that hold extensive certifications in functional and integrative medicine who not only lecture, mentor, and teach but also continue to practice full-time and harness decades of clinical expertise like Dr. Filomena Trindade. An internationally sought-after speaker, and mentor to hundreds of clinicians, Dr. Trindade continually scours literature for the latest research on hormonal and metabolic health. Her latest focus has been cardiovascular disease.

On today’s episode, we dive into the latest insights regarding cardiovascular disease in women with Dr. Filomena Trindade. We discuss the interplay between women’s hormones, insu...

Inflammation is your body’s way of protecting itself from infection, injury, or other insults. Chemical signaling molecules called ‘eicosanoids’ are responsible for creating pain, heat, swelling, and redness. Eicosanoids are made from fatty acids, or dietary fats. We’ve all heard of fish oil and omega-3s being important when it comes to lowering inflammation. But why?

In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’

Today on The Lab Report:

Dr. Dwayne Jackson has spent decades in medicine and physiology. He lectured and taught at some of the finest universities in the world. In addition to academia, Dr. Jackson has been a staple in the fitness industry - both as an athlete and trainer. He is recognized internationally for his award-winning research which has shaped our understanding of chronic stress and its impact on immunity, inflammation, and mental health.

In today’s episode, Dr. Dwayne Jackson combines his vast knowledge of physiology with his long career in the fitness industry to help us cut through some of th...

Amber Shaw is a Mind & Body Transformation Expert and the Founder of The Wellness Revolution. She works with women over the age of 40 to empower them to rediscover their confidence and create a sustainable lifestyle. Amber’s approach fosters consistency, accountability, and kindness. Women can be quite hard on themselves rather than show self-love. Shifting hormones, the demands of family and career, and a very confusing diet landscape can all be difficult to navigate. This is where Amber Shaw chose to build her career.

On today’s episode, Amber Shaw talks about helping women heal their relationship with...

Inflammatory bowel disease or IBD is an umbrella term to describe chronic inflammatory disorders of the GI tract – most commonly Crohn’s disease and ulcerative colitis. Medications, nutritional therapies, and lifestyle modifications are all used to control symptoms and keep patients in remission. However, sometimes surgical intervention is needed. Dr. Elizabeth Raskin is an award-winning colorectal surgeon and the Surgical Director of one of the leading IBD programs in the country – the Hoag Margolis Family IBD Program. This team-based, multidisciplinary approach to helping patients with IBD addresses the medical, nutritional, and psychosocial components to these diseases.

Today we spe...

Dr. Lauryn Lax is a Doctor of Occupational Therapy, Clinical Nutritionist, Functional Medicine Practitioner, Certified Personal Trainer, author, and journalist. With over 20 years of clinical and personal experience, she’s on a mission to help patients feel good - inside and out. But what sets Dr. Lauryn apart is her life-long journey of illness and healing. It’s a story of joy, pain, bravery, and survival. This journey has resulted in an empathic heart, a holistic philosophy, and tools that can transform lives.

In today’s episode, Dr. Lauryn Lax shares her incredible story of personal healing to hel...

The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse’ of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic.

In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don’t need to be treated.  

Tod...

Methane is often in the news as a greenhouse gas, but guess what? Your gut microbiome also makes it. Specific organisms called methanogens are responsible for the production of methane in the GI tract. High levels of methane can locally affect gut motility and contribute to constipation. In addition to constipation, methane affects gut immunity and has some interesting systemic implications. 

In today's episode, we talk about the effects of methane production in the GI tract, various ways to assess it, and what you can do to treat it when levels get too high. 

Today on...

Living with acne, or any chronic skin condition, can be incredibly distressing. Skin is the largest organ in our body and is forward-facing for the world to see. Conventional medicine offers creams, gels, and antibiotics. But in personalized medicine, we know that acne is multi-factorial and has several root causes. Lienna May is a board-certified clinical nutrition specialist who is dedicated to helping patients struggling with acne by developing personalized lifestyle and nutrition programs for patients to reclaim their health and clear their skin.

In today’s episode, Lienna May discusses the root causes of acne and ou...

Lacey Dunn is a functional medicine dietitian and personal trainer who is passionate about helping women look and feel their best. Lacey is the founder of Uplift Fit Nutrition (an online platform for personalized support), host of the Uplift Fit Nutrition Podcast, and author of the book “The Women’s Guide to Hormonal Harmony – How to Rebalance Your Hormones, Master Your Metabolism, and Become the Boss of Your Own Body.” Many of her clients call her their “Hormone Fairy Godmother.”

In today’s episode, Lacey Dunn gives a masterclass on the functional approach to balancing hormones and balancing your...

Dr. Mike T Nelson is an exercise physiologist, researcher, speaker, author, personal trainer, and coach. In the world of sports optimization, his approach to coaching world-class athletes is innovative and science-driven. Dr. Mike’s years of research and coaching experience, paired with an open mind to new ideas, have garnered his clients amazing results. A teacher at heart, he also offers several key training opportunities and certifications to help athletes, coaches, and healthcare professionals to fully understand the physiology that drives meaningful changes.

In today’s episode, Dr. Mike T Nelson outlines the basics of physiologic flexibility and...

Here at Genova, we are incredibly proud of the high standards set by our laboratory director and the brilliant minds that work in the lab to keep things running smoothly. As clinicians, and consumers, many of us don’t give the inner workings of the lab a second thought. We take for granted that samples are sent, results are generated, and we can clinically act on those findings. Most of our profiles rely on several different laboratory methodologies to put the whole story together. One of those methods is called Chromatography – and clinicians don’t fully understand what that actual...

The importance of B-vitamins can not be overstated. They are used as cofactors in just about every biochemical pathway in the body. Overt B-vitamin deficiencies are not common, though many diet and lifestyle factors can influence levels and lead to insufficiencies. Symptoms of B-vitamin deficiencies are widely variable and not often recognized. Many people choose to take B-vitamin supplements. But why? Should we all be taking a B-complex vitamin? Is it possible to take too much?

On today’s show, we do a high-level overview of B-vitamins. We talk about the importance of each B-vitamin in the bo...

Eating disorders have long been stigmatized and treatments have been limited – until now. Dr. Michael Lutter is a medical psychiatrist and PhD researcher working toward new solutions and therapies to offer hope for those suffering with psychiatric illness.  Using the latest advancements in genetic and metabolic testing, Dr. Lutter helps patients understand how their unique biology plays a role in their psychiatric disease and tailors treatment based on these findings. His results are astounding. His latest book GIFTED: Genetic Information for Treating Eating Disorders outlines his novel approach.

In today’s episode, Dr. Michael Lutter discusses precision psych...

Elite professional athletes are often held up as the healthy ideal. But many of us don’t realize the wear and tear and physical toll that sport takes on the body. That’s where Jaclyn Sklaver comes in. As a nationally recognized sports nutrition specialist, she combines functional medicine with personalized nutrition to create coaching plans for long-term success.

Today we meet Jaclyn Sklaver and hear about her unique Athleats Nutrition program. Whether you are an elite athlete or an everyday gym enthusiast, Jaclyn’s team at Athleats Nutrition can help you reach peak performance, optimal body compos...

Autoimmune conditions are exponentially on the rise. Toxic exposures, declining food quality, stress, and unhealthy lifestyle factors are all contributors. Dr. Akil Palanisamy is a Harvard-trained physician, author, and holistic medicine expert in integrative and functional medicine. Through years of experience in root-cause medicine, he’s helped thousands of patients find relief and remission of autoimmune diseases. Dr. Akil’s new book The T.I.G.E.R. Protocol: An Integrative, 5-Step Program to Treat and Heal Your Autoimmunity outlines his approach using the best of conventional and holistic medicine.

In today’s episode, we meet Dr. Akil P...