ciT1zen Science by the(sugar)science’s Podcast

In the thirty-fourth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Family History and Type 1 Diabetes Pathogenesis: Key Findings from the TEDDY Study.

ciT1zen science from the(sugar)science is devoted to helping the entire Type 1 Diabetes (T1D) community become more familiar with cutting edge science happening now. Podcasts and summaries to keep you informed. We curate and share important T1D science that you can understand, follow and enjoy.

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In the thirty-third episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Genetic risk-targeted islet autoantibody screening for presymptomatic type 1 diabetes in adults.

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In the thirty-second episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in Type 1 diabetes.

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In the thirty-third episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity.

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In the thirty-one episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Single-cell immune transcriptomics reveals an inflammatory–inhibitory set-point spectrum in autoimmune diabetes.

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In the thirty-second episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Diabetes research enters the biobank era: searching for the truth in a deep well.

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In the thirty-first episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Personalised prevention therapy in type 1 diabetes.

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In the thirtieth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis.

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In the thirty-second episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes.

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In the twenty-ninth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Engineering Stem Cell-Derived Beta Cells with Optimized CD155 for Immune Evasion in Type 1 Diabetes Therapy.

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In the thirtieth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Advancements in Type 1 Diabetes Curative Strategies.

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In the thirty-first episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Peripheral blood gene expression stratifies rate of progression to type 1 diabetes in autoantibody-positive children in the TEDDY study.

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In the twenty-ninth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Type 1 Diabetes Prevention: Screening and Intervention Strategies.

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In the twenty-eighth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Epigenetic Signatures Linked to Protection Against Type 1 Diabetes.

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In the thirtieth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Engineering Hypoimmune Stem Cell-Derived Beta Cells for Diabetes Therapy.

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In the twenty-nine episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Briefing on Antiasthmatic Drugs and Type 1 Diabetes Risk in Children.

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In the twenty-seventh episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Alpha-to-Beta Cell Communication in Pancreatic Islets.

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In the twenty-eighth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Clinical Characteristics of Autoantibody-Negative vs. Autoantibody-Positive Type 1 Diabetes in Children: A Swedish National Cohort Study.

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In the twenty-eighth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Autoimmune Type 1 Diabetes in the Era of Disease-Modifying Therapy.

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In the twenty-sixth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Hypoimmune stem cells and islets: hype or a true breakthrough in diabetes treatment?.

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In the twenty-seventh episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Peripheral Blood Endotypes in Pediatric Type 1 Diabetes.

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In the twenty-seventh episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the article These immune cells won Nobel fame — can they solve autoimmune disease?.

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In the twenty-sixth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper AI-driven early detection of type 1 diabetes.

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In the twenty-fifth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Gastrointestinal delivery of mRNA lipid nanoparticles selectively targets the pancreas.

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In the twenty-sixth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper System Failure in Type 1 Diabetes: What Stakeholders Need to Know to Expedite Therapeutic Options.

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In the twenty-four episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper The MELD-ATG Trial: Key Findings and Implications.

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In the twenty-fifth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper The Future of Type 1 Diabetes Therapy: A Synthesis of Transformative Breakthroughs.

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In the twenty-fifth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Genetic and Epigenetic Screens in Primary Human T Cells: A Synthesis of Key Findings.

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In the twenty-fourth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Twenty Years of Progress in Type 1 Diabetes Mellitus.

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In the twenty-third episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Deep tissue optical 3D imaging reveals preferential preservation of extra-islet β-cells in late-onset Type 1 Diabetes.

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In the twenty-fourth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Serum Metabolomics Reveals Potential Differences in Gut Microbiota–Associated Metabolites in Twins Discordant for Type 1 Diabetes.

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In the twenty-third episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Replacement of Beta Cells for Type 1 Diabetes.

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In the twenty-second episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper The Role of Vascular-Associated Fibroblastic Cells (VAFs) in  Tolerance and Type 1 Diabetes.

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In the twenty-third episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Event-triggered Smart Dual Hormone Artificial Pancreas (SDHAP).

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In the twenty-first episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice.

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In the twenty-second episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes.

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In the twenty-second episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?.

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In the twenty-first episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas. 

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In the twenty-first episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Profiling associations of interactive ligand-receptors (HLA class I & KIR gene products) with the progression to T1D among seroconverted participants.

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In the twentieth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Subcutaneous Abatacept in New Onset Type 1 Diabetes: Clinical and Immunological Effects. 

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In the twentieth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Illuminating the future of diabetes treatment: Autologous CiPSC-derived islets take center stage.

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In the twentieth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells.

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In the nineteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Epigenetic differences at immune and T1D susceptibility genes in blood from young children after COVID-19 infection. 

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In the nineteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Revisiting Glucagon Action in Diabetes: Is It All Bad?.

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In the nineteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression.

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In the eighteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Artificial intelligence and clinical trials: a framework for effective adoption. 

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In the eighteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Preparing clinical research data for artificial intelligence readiness: insights from the NIDDK Diseases data centric challenge.

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In the eighteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Chemical reprogramming of human blood cells to pluripotent stem cells.

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In the seventeenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Development and recalibration of a multivariable type 1 diabetes prediction model for T1D across multiple screening studies. 

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In the seventeenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Insulin Resistance in T1D: Concepts and Implications for Therapy.

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In the seventeenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper The antigen presentation landscape of cytokine-stressed human pancreatic islets.

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In the sixteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement.

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In the sixteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Persisting plasma proinsulin levels in a cohort of 482 individuals with long-standing type 1 diabetes mellitus. 

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In the sixteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Verapamil and low-dose anti-mouse thymocyte globulin combination therapy stably reverses recent-onset T1D in NOD mice by acting on the beta cell & immune axes.

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In the fifteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Hypertriglyceridemia in New-Onset Type 1 Pediatric Diabetes. 

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In the fifteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper PD-1 expressing islet-specific CD4+ T cells promote bystander tolerance and prevent autoimmunity.

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In the fifteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Genetic Risk and Transition through Preclinical Stages of Type 1 Diabetes.

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In the fourteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes. 

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In the fourteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Once-weekly basal insulin therapy in type 1 diabetes: A paradigm shift or a work in progress?.

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In the fourteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Improved conditioning for hematopoietic chimerism induces islet tolerance to cure diabetes.

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In the thirteenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the Ongoing Type 1 Diabetes Clinical Trials. 

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In the thirteenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper The Frequency but not the Phenotype of Circulating Peripheral T Helper Cells is Increased at Later Stages of Progression to Type 1 Diabetes.

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In the thirteenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Emerging Role of Gene Therapy in Immune Modulation and Beta-Cell Preservation in Type 1 Diabetes.

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In the twelfth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Type 1 diabetes mellitus prevention: present and future. 

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In the twelfth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in T1D: Prospective Longitudinal Study in Japanese T1D.

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In the twelfth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Pluripotent stem cell–derived extracellular vesicles for systemic immune modulation in diabetes therapy.

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In the eleventh episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with T1D: a randomized controlled trial. 

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In the eleventh episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells.

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In the eleventh episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Preproinsulin-specific regulatory T cell-derived exosomes loaded w/ immune-checkpoint ligands can suppress autoimmune responses in T1D.

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In the tenth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Prebiotic supplementation in patients with type 1 diabetes: study protocol for a randomised controlled trial in Canada. 

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In the tenth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Recent advances in early diagnosis and treatment of T1D with miRNAs.

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In the tenth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Novel methodologies for the treatment of type 1 diabetes mellitus using in silico tools.

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In the ninth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Global T1D prevalence, incidence, and mortality estimates 2025: Results from the International diabetes Federation Atlas.

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In the ninth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Partial remission of type 1 diabetes: Do immunometabolic events define the honeymoon period?. 

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In the ninth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in T1D.

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In the eight episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper A novel bioinformatics approach reveals key transcription factors regulating T1D-associated transcriptomes.

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In the eight episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset.

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In the eight episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Establishing the performance and acceptability of dried blood spot sampling to screen for islet-specific autoantibodies. 

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In the seventh episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Cathepsin S is elevated in pancreatic islets and plasma in new-onset type 1 diabetes and positively associates with systemic inflammatory cytokines. 

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In the seventh episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells.

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In the seventh episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Harnessing Machine Learning, a Subset of Artificial Intelligence, for Early Detection and Diagnosis of Type 1 Diabetes: A Systematic Review.

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In the sixth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Early Detection of Beta-Cell Decline using Home Dried Blood Spot C-Peptide Levels in New-Onset Type 1 Diabetes.

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In the sixth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Comparison of immunological and immunogenetic markers in recent-onset type 1 diabetes among children and adults. 

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In the sixth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Regulation of pancreatic β cells by exosomes from different sources.

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In the fifth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Hormone-switching islet cells: parallels to transmitter-switching neurons.

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In the fifth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.

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In the fifth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Repeated OGTT Versus Continuous Glucose Monitoring for Predicting Development of Stage 3 Type 1 Diabetes: A Longitudinal Analysis. 

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In the fourth episode of "Top Type 1 Diabetes Clinical Research This Week" we discuss the paper Type 1 diabetes risk factors, risk prediction and presymptomatic detection: Evidence and guidance for screening. 

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In the fourth episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Exosomes in Systemic Autoimmune Diseases: Recent Advances in Diagnostic Biomarkers and Therapeutic Applications.

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In the fourth episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Progress and challenges in developing allogeneic cell therapies.

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In the third episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Progress and challenges in developing allogeneic cell therapies.

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In the third episode of "Top Type 1 Diabetes Clinical Research This Week"  we discuss the paper Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features. 

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In the third episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Advances in cell therapy for the treatment of type 1 diabetes.

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In the second episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Exploration of individual beta cell function over time in vivo: effects of hyperglycemia and glucagon-like peptide-1 receptor (GLP1R) agonism.

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In the second episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper The Last Mile in Beta-Cell Replacement Therapy for Type 1 Diabetes: Time to Grow Up.

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In the second episode of "Top Type 1 Diabetes Clinical Research This Week"  we discuss the paper The stage- and subgroup-specific impact of non-HLA polymorphisms on preclinical type 1 diabetes progression. 

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In the first episode of "Understanding Type 1 Diabetes: The Basics" we discuss the paper Advances in basic biology and translation in islet research.

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In the first episode of "Top Type 1 Diabetes Clinical Research This Week"  we discuss the paper The need for a Type 1 Diabetes Scorecard. 

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In the first episode of "Top Type 1 Diabetes Basic Science Research This Week" we discuss the paper Genetic Protection from Type 1 Diabetes resulting from Accelerated Insulin mRNA Decay.

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