Oncology Unscripted With John Marshall

MedBuzz: From Hormones to Heroines: Couric, Cancer, and the Case for Change

John Marshall, MD
Hello, everybody. John Marshall for Oncology Unscripted, coming to you from my now almost empty office. I've been in this office for, gosh, 20-plus years. It's the big office. You may or may not know I stepped down as the division chief here at Georgetown. We planned it—I wanted to do it a while ago. They said no. So, I finally got to step down because I wanted to do some other things. I get a lot of time back fr...

MEDBUZZ [0:00:05]

When the Sources of Trusted Information Change—Who Do We Believe?

John Marshall, MD:
Happy whatever day it is today when you're watching this. John Marshall for Oncology Unscripted. A little bit of a rainy day here in Washington, DC. It's been a little bit of a weird time here in Washington, DC—even weirder than it normally has been.

Let's start with a little of the business of our world today—the business of oncology. You may have seen that we have a new National Cancer Institute director: Dr Anthony. Profes...

[00:00:05] Main Topic 

ESMO, Efficiency, and Evidence: New Data, China’s Science Leap, and Leucovorin and Autism 

John Marshall, MD: Hey everybody, John Marshall from Oncology Unscripted. There is so much going on right now that we're gonna need a full hour-long show, but we're not gonna do that to you. We still promise short bites here and there of the stuff that's going on, just to make sure you're in the loop. I'm sure you are.

But let's start with a little science. And the science we wanna focus on is the upcoming ESMO...

[00:00:05] MedBuzz: Back to Being ‘Just a Doctor’

John Marshall, MD: John Marshall for Oncology Unscripted, coming to you live from this big office. This is the biggest office because, you know, I've been the Chief of the Division here at Georgetown for 20 years. I didn't want the job when I was first offered it a long time ago. I ended up saying yes. Of course, that's a dramatic change in one's academic career—taking on administrative roles like this. You do get the big office, which is nice, but you also get a lot of other stuff. You kn...

Why Are More Healthy Young Adults Getting GI Cancer?

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John Marshall, MD:
John Marshall for Oncology Unscripted. Big paper coming out of _JAMA_—it's actually a review article. Really, really smart people and friends up in Boston looked at this. We all see it: this emerging trend of younger and younger people getting all kinds of cancer. This particular paper wasn’t about all kinds of cancer, but we’re clearly seeing it in GI cancers. We don’t really understand what’s going on, but we see it—it’s impacting our clinic. Maybe it was f...

ACCESS THROUGH INNOVATION: THE POWER OF SMARTER CANCER CARE STRATEGIES

[00:00:05] John Marshall, MD: John Marshall for Oncology Unscripted. Really no script at all, but we are post-ASCO here in Washington, DC, trying to take all of those major innovations that we all get so excited about—curves with big deltas that we saw in all sorts of different cancers, including the humblest of them all: GI cancers.

So, now the question is: how do you take those innovations and those changes—some of them are added to NCCN, some of them may be FDA-approved, some of t...

“Badge-up” with Dr Marshall at ASCO 2025

John Marshall, MD: John Marshall coming to you live Oncology Unscripted, not from my office back in Georgetown, but from beautiful downtown Chicago, Illinois at ASCO 2025. Look at this amazing place. 40,000 of our closest friends.

To get in, you need to have one of these. So, I'm gonna go ahead and badge up. I got a fancy red collar thing here, boy, that makes me stand out even that much more.

But what we're gonna talk about today first is the social aspect. You remember in anticipation of c...

Badges, Booths, and Buses: Welcome to ASCO 2025

John Marshall, MD: John Marshall Oncology Unscripted. You know what this is? Yeah. You know what this is. This is my ASCO badge. It is that time of year again where I. I don't know, 40, 50, 60,000 of us and our closest friends all fly up to Chicago, stay in hotels that are overpriced, get bused around downtown Chicago, even on Saturday and Sunday. We get in nice clothes. We go to the convention center. We probably share a virus or two, but we mostly share important new information around the world...

No Evidence of Disease—No Need for the Knife?

John Marshall, MD: John Marshall for Oncology Unscripted. Let's talk a little science and cancer medicine. I’m gonna come at you from a little bit of a different angle. Yep. A GI cancer angle, but a little bit different.

We have long felt in order to cure GI cancers, we had to do surgery, that it was the only way to ultimately cure people. But we all know that when we do neoadjuvant something could be chemo chemoradiation. we operate. A certain sub portion of the...

We Funded the Cure—Now We're Pulling the Plug?

John Marshall: Welcome to Washington DC. My name is John Marshall. This is Oncology Unscripted. There is a whole lot of stuff going on out there, seemingly unscripted, seemingly without much in the way of a sense of motivation, really a plan. It's just blow it up. Let's see what'll happen after the fact. 

But let's stop for just a second and think about what science, federally funded science, has accomplished over the last many decades here. Because a lot of us, including a lot of the...

Published, Performed, Passed Over—Because Science Still Has a Gender Problem

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John Marshall, MD: John Marshall, Oncology Unscripted. It's unscripted because you can't make this stuff up. I don't know if your week or the last two has been anything like mine, but our country and our science and healthcare, and all of that stuff, is really undergoing an incredible number of changes so quickly that we can't even catch up with what the impact will be. And maybe It's only because we're in health care, but I gotta believe that the impact that all of...

THE WEIGHT OF THE WHITE COAT: BATTLING BURNOUT

How Do Middlemen Impact Our Practices? [00:00:00]

John Marshall, MD: Welcome back everybody to Oncology Unscripted. It is August and if you're lucky like I am, August is vacation time for me. I am at this beautiful place somewhere in the south, somewhere near a golf course and an ocean; a little river flowing right over there, some egrets and an occasional pelican flying by. There are fruity rum drinks, most evenings, which makes for a very pleasant time away from work. So, I'm on vacation, and I...

John Marshall, MD: Hey, everybody. John Marshall with Oncology Update. Welcome back. This is episode 5. 

We now have a really cool function called ask a question. Click on that. Send us something. We hope to get back with you with an answer.

Most of the time, you know, you see these things and it's all nailed down, and you know exactly what you're about to get. Not so much with this. We’re really trying to bring to you the current days news. What's going on in our world in the world of cancer, both in...

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John Marshall, MD: Hey everybody, this is, believe it or not, episode four of Oncology Update, where we're really trying to get to, God should we say it, the truth in oncology. There's so much going on out there. It's a complex business. There's a lot of really cool science. There's a lot of progress going on. We're affecting a lot of people's lives, including our own. 

So, let's jump right in and see what's going on out there this week. 

Remembering the Father of Tamoxifen

[00:00:31] I don't know if you sa...

Oncology Update: Introduction [00:00:00]

John Marshall, MD: Welcome back to Oncology Update. My name is John Marshall here from Georgetown University, Washington, D. C., the land of freedom. I don't know what it is the land of anymore, but welcome back to Episode 3 of Oncology Update. 

Our theme for this session is going to be, how do you stay up to date? How do your patients stay up to date with all that's going on in the world of oncology? And are you, in fact, delivering state-of-the-art treatment? Or are you, in fact, maybe delivering something, s...

John Marshall, MD: Hey everybody, John Marshall for Oncology Update. Believe it or not, second episode. They let me do a second one. There's bad judgment on their part.

ASCO Buzz

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We're just back from ASCO, so you know how everybody's doing. You're still trying to pile out of your emails and figure out if you're actually going to get reimbursed for that dinner or not try for it. You never know. It might work out. 

Let's start and kind of reflect a bit on this meeting, that is ASCO. You k...

[00:00:00] John Marshall, MD: Hey, everybody out there. This is John Marshall live from my office at Georgetown University. And this is oncology update for May 22, 2024. We're about one week out from ASCO. There's a lot going on, but first let's talk a little bit about what's going on out there in our business world in oncology today.

Shifts & Shocks: Layoffs, Dose Reductions, and Drug Withdrawals

[00:00:27] There’s been a crazy lot of stuff happening. First, I don't know if you saw this, but Bayer laid off a thousand plus people or will do that over th...

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John Marshall, MD:

Hey, everybody, John Marshall back for oncology unscripted. If you've been silly enough to further away your time with me, we're now on the 7th episode, believe it or not. Goodness gracious, the sponsors of this are crazy to let me keep going. 

But we do have some really cool stuff to talk about today, and I hope you'll listen in as I review not only sort of what's going on in our world, a little bit of gossip, a little bit of business, we're going to talk about the l...

[00:00:05] John Marshall, MD

Hello, everybody. John Marshall from Oncology Unscripted. Do you know where I was this past weekend? I was in San Francisco. It's actually pretty nice weather there in San Francisco. I go pretty much every year. In fact, I have gone to every GI ASCO. 

Skipping This Test in Frontline Metastatic Colon Cancer? That’s Malpractice.

[00:00:24] It's really usually my first business trip of the year. Usually, the weather out in San Francisco is kind of rainy and gloomy in the fifties, but it was pretty sunny compared to here out...

The Economics of Cancer Care: Who Pays for Progress? 

John Marshall, MD: What do you guys think? What do you think I'm looking like today here in Washington D.C. In January 2025? Well, What I'm trying to look like is the new administration, which is moving in just down the street from me there. 

There is an unfortunate casket, a hundred-year-old man inside, draped in the American flag. What I think of as a sort of heroic politician. And in a couple of weeks, we're going to have a parade here for next wave of po...

MedBuzz: The PBM Pushback

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John Marshall, MD: Ho, Ho, Ho, everybody out there. This is John Marshall for Oncology Unscripted, and we're going to talk a lot about pancreatic cancer today. We're also going to talk about some other things as well, but I thought I would sort of start off with a little holiday story. 

See that stocking? I've had this stocking for a long, long time. I actually keep it right over there in my drawer, and it's a reminder of what we do for a living. So, a patient almost 30 y...

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Is the Inflation Reduction Act a Threat or Opportunity for Oncology?  

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[00:00:05] John Marshall, MD: Hey everybody, John Marshall live from Washington DC where all the action is happening. A lot of moving vans are likely to be coming here soon as the new party comes in to take over maybe everything. We're going to have to see how that goes. We're all living in this crazy state of uncertainty about just how much. Are they saying is going to happen? But we'll see. That's our future. 

[00:00:34] But what I really want to...

Monopoly Concerns with Oncology Acquisitions: Should We Be Worried 

[00:00:05] John Marshall, MD: John Marshall, MD: Hey, everybody, John Marshall with Oncology Unscripted, even though I've got a little bit of a script right here, but don't tell anybody. Today, we're going to talk all about dosing of medicine, and do we have it right or not, particularly with some of our newer cancer medicines. And I'm going to really drill down on a couple that I know a lot about that I hope you will use in your own practice, quite honestly, and make your life a l...

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