March Forward
By: March.ai
Language: en-us
Categories: Health, Fitness, Medicine, Science, Life
Welcome to the March Forward podcast, a space dedicated to the rare disease community. We understand the unique challenges you face, from the 'diagnostic odyssey' to navigating complex treatments and the emotional toll of caregiving. Our podcast aims to provide clear, trustworthy, and in-depth information, fostering hope and support as we explore the latest advancements in rare disease research and care.
Episodes
Is a Clinical Trial the Right Path for My Rare Disease?
Dec 15, 2025Send us a text
Considering a clinical trial can bring up a lot of emotions, hope, uncertainty, and so many questions. For those in the rare disease community, it often represents a path toward new possibilities, but it’s a big decision that can feel complex. You don't have to figure it all out by yourself. 🤝
We believe you deserve clear, honest information to help you find the path that’s right for you. We created this guide to walk with you through the process, explaining things in a way that’s easy to u...
Duration: 00:16:01Can Personalized Medicine Finally Help Rare Disease Patients?
Dec 09, 2025Send us a text
What if your treatment was as unique as your own DNA? 🧬
For so many in the rare disease community, the dream of a therapy tailored specifically to their body is now becoming a reality. This isn't science fiction; it's the hopeful, rapidly advancing field of personalized medicine. ✨
In this episode of March Forward, we explore how personalized medicine is transforming the approach to rare diseases. We move beyond "one-size-fits-all" solutions to discuss treatments designed for your unique biological blueprint.
We’ll also look at real-world examples like Zo...
Can AI Accelerate Drug Repurposing for Rare Diseases?
Dec 01, 2025Send us a text
What if we told you that AI is helping us find new uses for existing medicines, bringing us closer to treatments for rare diseases? 🔍 🔬
In this episode of March Forward, we gently explore how Artificial Intelligence is transforming drug repurposing, offering a new horizon of hope for patients and families navigating rare conditions. We discuss how AI sifts through vast amounts of data to uncover hidden connections between existing drugs and rare diseases, significantly speeding up the journey to potential treatments.💡
Learn how this innovative approach reduces development time and costs...
Duration: 00:25:41How Can We Cope with the Mental Toll of Rare and Chronic Illness?
Nov 24, 2025Send us a text
Have you ever felt that living with a rare or chronic illness comes with an unseen weight, a battle fought not just in the body, but in the mind too? 🧠
In this episode of March Forward, we gently explore the profound emotional and psychological impacts that often accompany rare and chronic conditions. We discuss the often-arduous "diagnostic odyssey" and how it, along with the daily realities of illness, can lead to feelings of sadness, anxiety, and a deep sense of grief for the life that was. 💔
We’ll...
Duration: 00:16:06How SHEPHERD AI Can Help with Quicker Rare Disease Diagnoses
Nov 17, 2025Send us a text
The search for a rare disease diagnosis can be a long and lonely journey. But what if advanced technology could help light the way? 🔍
In this episode of March Forward, we're exploring SHEPHERD, an innovative AI approach bringing new hope to rare disease diagnosis. SHEPHERD uses a clever "few-shot learning" method, allowing it to learn effectively even from limited patient information. It also uses a deep rare disease knowledge graph, acting like a vast, interconnected map to find important connections for your unique health picture. 🧠
This isn't just theory. SHEPHE...
Duration: 00:24:07C2S-Scale: Yale & Google's AI That Reads Cells. Will It Work for Rare Diseases?
Nov 10, 2025Send us a text
A new collaboration between Yale and Google just released C2S-Scale, a 27-billion parameter foundation model that's learned to "read" cells by converting gene expression into text.
It's already predicted a validated cancer therapy combination that worked in the lab. But here's the question that matters to our community: What can this tool actually do for rare diseases? 💡
In this episode of March Forward, we're not just celebrating the hype; we're asking the hard questions that patients and families need answered:
🔬 Can it work reliably for rare disease...
Duration: 00:21:46What's inflammation got to do with your rare disease?
Nov 03, 2025Send us a text
Could inflammation be the missing piece in your rare disease puzzle? 🤔
If you're living with a rare condition, understanding your body's inflammatory response might be the key to better management and relief. 🔥
In this episode of March Forward, we break down how inflammation actually works in rare diseases, from what triggers it to why it can spiral out of control. We'll explore the signals your body sends (called cytokines) and how they can turn against you, creating cycles of damage that feel impossible to escape. 🌀
We'll also cover the...
Duration: 00:19:46The First Therapy to Unlock Trapped Immune Cells in WHIM Syndrome
Oct 27, 2025Send us a text
Imagine your body's best defenders, your immune cells, are ready for duty but locked away, unable to fight. 🛡️ For individuals with the ultra-rare WHIM syndrome, this isn't just an idea; it's the biological reality they live with every day.
In this episode of March Forward, we explore WHIM syndrome, a genetic condition where a faulty signal traps vital white blood cells in the bone marrow. But this is also a story of a major breakthrough ✨.
We dive into the science behind Mavorixafor, the first-ever targeted oral therapy designed to "unlock the barracks...
Fidanacogene Elaparvovec for Hemophilia B
Oct 20, 2025Send us a text
Imagine your body's best defenders, your immune cells, are ready for duty but locked away, unable to fight. 🛡️ For individuals with the ultra-rare WHIM syndrome, this isn't just an idea; it's the biological reality they live with every day.
In this episode of March Forward, we explore WHIM syndrome, a genetic condition where a faulty signal traps vital white blood cells in the bone marrow. But this is also a story of a major breakthrough ✨.
We dive into the science behind Mavorixafor, the first-ever targeted oral therapy designed to "unlock t...
Duration: 00:17:18Afamitresgene Autoleucel (Tecelra) for Synovial Sarcoma
Oct 13, 2025Send us a text
What happens when standard treatments for a rare cancer like synovial sarcoma fall short? Could Empowering the answer lie in empowering your own immune system? 🛡️
In this episode of March Forward, we explore Afamitresgene Autoleucel (Tecelra), an innovative cell therapy offering a new avenue of hope for patients with advanced synovial sarcoma. This cutting-edge treatment takes a patient's own immune cells, 're-educates' them in a lab to specifically target cancer cells (targeting MAGE-A4, a protein often found in synovial sarcoma), and then reinfuses them as a personalized fighting force.
Learn...
Duration: 00:21:04Can In-Body Gene Editing Help Cure Rare Genetic Diseases?
Oct 05, 2025Send us a text
What if we could gently fix the tiny genetic 'typos' that cause devastating rare diseases, right where they are in the body? 🧬
In this episode of March Forward, we dive into In Vivo CRISPR Base Editing, a cutting-edge science offering a new horizon of hope ✨ for patients and families navigating rare genetic conditions. We explore how this groundbreaking technology aims to make ultra-precise changes to DNA inside the body, potentially correcting the root cause of certain diseases.
Learn how this innovative approach differs from other gene editing techniques and what...
Enzyme Replacement Therapy for Lysosomal Storage Diseases
Sep 29, 2025Send us a text
For families navigating Lysosomal Storage Diseases, the routine of Enzyme Replacement Therapy is a familiar path. But what if the future holds new and different options? In this episode of March Forward, we're exploring the cutting-edge science that could change how we treat these complex conditions.
We're asking the big questions that many in our community think about:
🧠 Can we get treatments safely past the blood-brain barrier?
🤔 How do you weigh a proven, lifelong therapy against a one-time treatment with unknown long-term effects?
🔬 Are we getting closer to...